Trulance vs Linzess: A Comprehensive Comparison

When it comes to managing gastrointestinal disorders like chronic constipation or irritable bowel syndrome with constipation (IBS-C), healthcare providers often prescribe medications to alleviate symptoms and improve patients’ quality of life. Two commonly prescribed medications for these conditions are Trulance vs Linzess. In this article, we will provide a comprehensive comparison of Trulance vs. Linzess to help you understand the differences between these medications and make an informed decision about your treatment.

What are Trulance and Linzess?

Linzess vs Trulance are both prescription medications used to treat chronic constipation and IBS-C. They belong to a class of drugs known as guanylate cyclase-C agonists, but they have some differences in terms of their chemical composition and formulation.

Trulance contains the active ingredient plecanatide, which is designed to increase fluid secretion in the intestines, making it easier to pass stool. On the other hand, Linzess contains linaclotide, which works by increasing the secretion of fluids and accelerating the movement of stool through the digestive tract.


Both Trulance and Linzess are primarily indicated for the treatment of two gastrointestinal conditions:

  1. Chronic Constipation: These medications can help relieve constipation by promoting bowel movements.
  2. Irritable Bowel Syndrome with Constipation (IBS-C): Trulance and Linzess are also approved for managing the symptoms of IBS-C, including abdominal pain and discomfort, bloating, and constipation.

Mechanism of Action

The key difference between Trulance and Linzess lies in their mechanism of action. Trulance specifically activates the guanylate cyclase-C receptor in the intestines, leading to increased fluid secretion and softer stools. Linzess, on the other hand, activates the same receptor but also enhances intestinal transit, helping to move stool through the digestive tract more rapidly.


Both medications have been found to be effective in treating chronic constipation and IBS-C, but individual responses may vary. Clinical trials have shown that Trulance and Linzess can increase the frequency of bowel movements and improve stool consistency in patients with these conditions. However, some individuals may respond better to one medication over the other.

Dosage and Administration

The recommended dosage for Trulance is typically 3 milligrams (mg) once daily, taken orally with or without food. Linzess is available in two dosage strengths: 145 mcg and 290 mcg. The usual starting dose for Linzess is 145 mcg once daily, but healthcare providers may adjust the dosage based on individual patient needs.

Side Effects

Like all medications, Trulance and Linzess can cause side effects. Common side effects may include diarrhea, abdominal pain, and flatulence. However, Trulance is generally associated with a lower incidence of diarrhea compared to Linzess. It’s essential to discuss potential side effects with your healthcare provider before starting either medication.


Both Trulance and Linzess have a relatively good safety profile when used as directed. However, they are not suitable for everyone. It’s important to inform your healthcare provider about your medical history, current medications, and any allergies before starting either medication to ensure they are safe and appropriate for you.

Cost Comparison

The cost of Trulance and Linzess can vary depending on factors such as your insurance coverage and the pharmacy you use. Some patients may find that one medication is more affordable than the other, so it’s worth checking with your insurance provider and comparing prices at different pharmacies.

Patient Reviews

To gain insight into the real-world experiences of patients using Trulance and Linzess, it’s helpful to read patient reviews and testimonials. Online forums and support groups can provide valuable information about the effectiveness and tolerability of these medications.

Interactions with Other Medications

Before starting Trulance or Linzess, it’s crucial to inform your healthcare provider about all the medications, supplements, and herbal products you are taking. Some medications may interact with Trulance or Linzess, potentially affecting their effectiveness or safety.

Choosing Between Trulance and Linzess

The choice between Trulance and Linzess should be made in consultation with your healthcare provider. Factors to consider include the severity of your symptoms, your response to previous treatments, your medical history, and your personal preferences. Your healthcare provider can help you make an informed decision that is tailored to your specific needs.


In summary, both Trulance and Linzess are effective medications for treating chronic constipation and IBS-C. They work through slightly different mechanisms and may have varying side effects. Ultimately, the choice between these medications should be based on individual patient factors and the guidance of a healthcare provider.

Frequently Asked Questions

Are Trulance and Linzess available over the counter?

No, both Trulance and Linzess are prescription medications and are not available over the counter.

Can I take Trulance and Linzess together?

It is not recommended to take Trulance and Linzess together without consulting a healthcare provider, as they may have additive effects.

How long does it take for Trulance and Linzess to start working?

The onset of action may vary, but some patients may experience relief within a few days of starting treatment.

Are there any dietary restrictions while taking Trulance or Linzess?

There are no specific dietary restrictions associated with these medications, but it’s essential to maintain a healthy diet and stay hydrated.

What should I do if I miss a dose of Trulance or Linzess?

If you miss a dose, take it as soon as you remember. However, if it’s close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Leave a Comment